After you create a new project , give it a name choose a location etc....
1. Setup your Arrange page, Mixer window layout, tempo and whatever to however you like.
eg. I set my tempo to 172. Currently this is usual tempo for Nuero(phace, noisia, misanthrop... (they switch it up sometimes).
2. I then add group busses ( drums, bass etc), fx busses and midi tracks and anything else you use regularly.
Me, i add Kontakt 3 and Minimoog.
3. I also set up Voxengo Span on the Master out etc.
4. Now, most importantly, do not start making beats straight away! go to file and select "save template"
Cubase then asks you to save a name for your template.
Call it whatever you want... cubase template v1 etc
and then.... your ready to go.
hope that helps.