I use Serato and love it. However it's so much easier to use Cd's unless Serato is set up beforehand. I miss the use of cue points/quick loading of tracks/using turntables and folder options Serato offers but if changing from vinyl to digital, go with Cd's for the ease of playing out. I have to put up with the set up of Serato which goes smoothly 8/10 times.
Until Serato is part of a club's standard set up (like, I believe in America/Canada), or you are high profile enough to have it in your contract when booked (Shy Fx, Netsky), it is annoying for you and others.
hope this helps.