It depends on sampler/DAW. In Ableton Live with Warp turned on you can change pitch without affecting the tempo of audio clips. In Logic there is Time and Pitch Machine. In Kontakt there is I believe an option to do this as well.
Chop the break, play the break on a slower bpm and pitch the sections of the break a few semitones down to avoid a chopping effect, then pitch it up back to the desired bpm.
The final pitch always depends on the recorded bpm and the global pitch of the break sections.
I discovered (well, actually I already knew it, but I was lazy to try) that you can use Harmor (of course, for Fl Studio), and it's capability of resample to pitch things, without affecting the quality of the sample.