WOW! This is a real bomb! I would say don´t lowpass that main melody, bring up your sub to something like -6dB. Try to highlight your drums more, it´s the case of making everything else quieter or boosting drums a lil. Very good build-up. Mid-bass seems tad too distorted or greasy. I love this tune so much, great work mate!
This is definitely a nice tune. I basically agree with Quotec, either open the filter on your reese, or even try having a second one playing the same thing with the filter open and maybe some different eq. And maybe fatten the drums up a bit unless you're going for the synth drum sound, in which case just bring them forward in the mix. I'd sidechain the sub and mids to the kick and snare hits so the drums cut through.